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Hamburg 1 ist ein privater Hamburger Regional-Fernsehsender. Er hat eine technische Reichweite von zirka 1,9 Millionen Haushalten und sendet über die Grenzen der Stadt hinaus, per Kabel bis Kaltenkirchen, Büchen, Harsefeld und Lüneburg. Er ist. Informationen über Cookies auf dieser Website. Um unsere Webseite für Sie optimal zu gestalten und fortlaufend verbessern zu können, verwenden wir Cookies. Hamburg 1 ist ein privater Hamburger Regional-Fernsehsender. Er hat eine technische Reichweite von zirka 1,9 Millionen Haushalten und sendet über die. HH1 Sendungen. Gestern; heute; Sa; So; Mo; Di; Mi; Do; diese Woche; nächste Woche; 14 Tage. Das aktuelle TV-Programm vom Do nur Tipps nur Live-. Der Hamburger Stadtsender Hamburg 1 zeigt Nachrichten aus Politik, Wirtschaft, Kultur und Sport sowie Magazine, Reportagen und Talkshows.
HH1 Sendungen. Gestern; heute; Sa; So; Mo; Di; Mi; Do; diese Woche; nächste Woche; 14 Tage. Das aktuelle TV-Programm vom Do nur Tipps nur Live-. Seiten umfaßt und beim HH1-Gesellschafter Axel Springer Verlag von sieben Redakteuren erstellt wird. Von Marketingchef Conrad Politt wird er vor allem. Hamburg 1 ist ein privater Hamburger Regional-Fernsehsender. Er hat eine technische Reichweite von zirka 1,9 Millionen Haushalten und sendet über die Grenzen der Stadt hinaus, per Kabel bis Kaltenkirchen, Büchen, Harsefeld und Lüneburg. Er ist.
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Seller assumes all responsibility for this listing. Item specifics Condition: Pre-owned : An item that has been used previously. The item may have some signs of cosmetic wear, but is fully operational and functions as intended.
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All items will be shipped from Japan. We will cover the shipping fee and the insurance. We will cover the shipping fee and the insurance..
We can not ship the item to Japan. Delivery time 1. Your item will be shipped out within 3 business days after the purchase. Items usually takes approximately business days to be delivered.
The end point for survival was euthanasia due to weight loss or substantial discomfort. Mice euthanized because of tumor diameter larger than 20 mm were censored.
The mice were euthanized if the WBC was lower than 1. In experiment 3, there were no statistical differences in survival between any of the groups data not shown.
The reason for this result was that the mice in the control group were euthanized due to tumor size and therefore censored out of the survival analysis.
The results for tumor growth will be reported elsewhere. WBC, RBC and platelets were measured before injection and at several time points after injection in experiments 1 and 2, and before injection and at euthanasia in experiments 3 and 4.
Blood samples were taken before treatment, 1 month after treatment and at euthanasia. The weight loss was severe after 10 days, which was considered to be an indirect symptom of radiation toxicity since no deleterious changes to the gastrointenstinal system were observed.
The weight loss was probably related to less food intake of sick mice. Error Bars: Standard deviation.
Blood samples were taken before treatment and at euthanasia. There were no significant changes in the urea values. The changes in the serum concentrations of these liver enzymes might indicate liver damage.
This explains the large error bars at this time point in Figure 4A. This mouse did not show any symptoms of illness or discomfort, hematology values were normal, and it was euthanized at the end of the experiment, not due to any clinical signs or symptoms.
Hematology values were normal. The mouse was euthanized at this time point due to weigh loss and rectal prolapse. The main organs affected were the bone marrow, lymph nodes, spleen and ovaries Table 2 , Figure 5.
Normal spleen from a control mouse. Normal lymph node from a control mouse showing diffuse interstitial cell hyperplasia.
This is a common background finding noted in the lymph nodes from athymic nude mice. Normal bone marrow from a control mouse.
These changes were considered to be non-specific changes related to the increased susceptibility of nude mice to infections.
However, the presence of microscopic lymphoma infiltration was observed in spleen, lymph nodes, pancreas or liver in both control and treated mice from experiment 1, with a slightly decreased incidence in treated animals.
This change was characterized by the presence of dense sheets of round to polygonal cells up to 40 micrometers in diameter. The lymphoma infiltration was probably due to lymphoma cells from the subcutaneous xenografts with which these mice were originally implanted.
We have previously shown good therapeutic effects of Lu-HH1 in SCID mice  and relatively high tumor uptake and low normal tissue uptake in nude mice .
The expected target organ for toxicity of Lu-HH1 is bone marrow due to retention of the RIC in the blood and, binding to tumor cells if present, in the bone marrow.
The toxicity is expected to be transient since normal stem cells do not express CD37 and will therefore be damaged only by cross-fire radiation and not by direct radiation from bound RIC.
The study indicates that the dose limiting organ is the bone marrow. This finding is in agreement with previous studies showing that the most common and dose-limiting side effect of RIT in lymphoma is bone marrow toxicity .
In addition, both the MTD and the dose-limiting organ observations are in good agreement with results from another study of Lu-CC49 a murine IgG 1 reactive with the tumor-associated antigen TAG .
It is, therefore, apparent that Lu-labeled antibodies are more toxic for SCID mice than for nude mice. The reason why the MTD for humans is more similar to the MTD for SCID mice than for nude mice may be related to differences in DNA repair capacity between rodent and human cells, or it could be attributed to the large differences in tumor targeting and normal tissue uptake and retention between rodents and humans.
HH1 is not cross reactive to mouse B-cells and hence, only non-specific binding of the RIC and cross-radiation from specifically bound RIC to the tumor xenograft will contribute to the absorbed radiation dose in nude mice.
Ovarian atrophy and interstitial cell hyperplasia were observed in some of the treated animals. The interstitial cell hyperplasia has been reported to accompany ovarian atrophic changes  , .
The present study does not allow to conclude if these changes are age-related or if there is any contribution from the Lu-HH1 treatment.
We hypothesize that the increase in ovary atrophy observed in the treated animals could be related to the radiation dose to ovaries due to cross-fire radiation from the kidneys, where Lu-HH1 has a modest uptake .
The ovaries are separated from the kidneys by a thin layer of fat so that part of the beta-radiation from Lu in the kidneys can reach the ovaries, since the maximum range of the beta-radiation is 1.
If this is the cause of the changes observed in mouse ovaries, this effect should not be expected in humans. The dose-limiting toxicity occurred in the bone marrow and manifested as low blood cell counts a few weeks after administration of the RIC.
The long term follow up data indicated only modest late toxicity in this murine model of human B-cell NHL.
The toxicity profile of Lu-HH1 presented in this paper, combined with the previously published study demonstrate that Lu-HH1 has a similar biodistribution in nude mice to that of the clinically tested Lu-rituximab  , .
This study suggests that Lu-HH1 is suitable for clinical evaluations. The dose-limiting toxicity occurred in the bone marrow and manifested itself as low blood cell counts a few weeks after administration of the RIC followed by a return to normal ranges.
The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. National Center for Biotechnology Information , U.
PLoS One. Published online Jul Ada H. Repetto-Llamazares , 1 , 2 Roy H. Roy H. Larsen 3 Sciencons Ltd. Anna Maria Giusti 4 Accelera Srl.
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